SDZ-MKS 492
| 中文名稱(chēng) | SDZ-MKS 492 |
|---|---|
| 中文同義詞 | 化合物 T12873;化合物 SDZ-MKS 492 |
| 英文名稱(chēng) | SDZ MKS 492 |
| 英文同義詞 | SDZ MKS 492;MKS 492;1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-;SDZ MKS 492,SDZMKS 492 |
| CAS號(hào) | 114606-56-3 |
| 分子式 | C20H27N5O6 |
| 分子量 | 433.46 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 114606-56-3.mol |
| 結(jié)構(gòu)式 |  |
SDZ-MKS 492 性質(zhì)
| 沸點(diǎn) | 648.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.36±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | DMSO：250 mg/mL（576.75 mM；需要超聲波） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.25±0.10(Predicted) |
| 顏色 | 白色至米白色 |
SDZ-MKS 492 (MKS 492) 一種選擇性的環(huán)狀 GMP 抑制的磷酸二酯酶 (III 型 PDE) 抑制劑。SDZ-MKS 492 抑制豚鼠和大鼠中抗原或血小板活化因子 (PAF) 誘導(dǎo)的支氣管收縮和過(guò)敏反應(yīng)。
type III phosphodiesterase
MKS 492 relaxes airway smooth muscle in vitro.
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs.
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs.
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs.
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats.
| Animal Model: | Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum |
| Dosage: | 3, 10 mg/kg |
| Administration: | I.v. 5 min before antigen challenge |
| Result: | Inhibited antigen-induced bron choconstriction in a dose-related manner. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100164 | SDZ-MKS 492 | 114606-56-3 | 1 mg | 1590元 |
| 2026/06/05 | HY-100164 | SDZ-MKS 492 SDZ-MKS 492 | 114606-56-3 | 5mg | 3500元 |