鹽酸克林沙星
| 中文名稱 | 鹽酸克林沙星 |
|---|---|
| 中文同義詞 | 7-(3-氨基-1-吡咯烷基)-8-氯-1-環(huán)丙基-6-氟-1,4-二氫-4-氧代-3-喹啉羧酸鹽酸鹽;鹽酸克林沙星;包被鹽酸可林沙星;克林沙星鹽酸鹽 |
| 英文名稱 | Clinafloxacin hydrochloride |
| 英文同義詞 | CLINAFLOXACIN HCL;CLINANFLOXACIN HYDROCHLORIDE;Clinafloxacinhydrochloride;7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride;7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-keto-quinoline-3-carboxylic acid hydrochloride;7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride;7-(3-azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride;3-Quinolinecarboxylic acid, 7-(3-aMino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI) |
| CAS號 | 105956-99-8 |
| 分子式 | C17H18Cl2FN3O3 |
| 分子量 | 402.25 |
| EINECS號 | |
| 相關(guān)類別 | 醫(yī)用原料;醫(yī)用原料;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol文件 | 105956-99-8.mol |
| 結(jié)構(gòu)式 | ![]() |
鹽酸克林沙星 性質(zhì)
| 熔點 | 162-168°C |
|---|---|
| 儲存條件 | Refrigerator |
| 溶解度 | DMSO(微溶)、甲醇(微溶)、水(微溶、加熱) |
| 形態(tài) | 固體 |
| 顏色 | 淡黃色至淺黃色 |
| 穩(wěn)定性 | 吸濕性 |
MIC: 1 μg/ml (parC-gyrA mutants, S. pneumonia )
Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus . It against Wild type S. aureus , gyr A?mutant S. aureus and gyr A?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively.
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-B0536A | 鹽酸克林沙星 Clinafloxacin hydrochloride | 105956-99-8 | 5 mg | 245元 |
| 2026/06/05 | HY-B0536A | 鹽酸克林沙星 Clinafloxacin hydrochloride | 105956-99-8 | 10 mg | 385元 |
