FRAKEFAMIDE
| 中文名稱 | FRAKEFAMIDE |
|---|---|
| 中文同義詞 | 化合物 T11323L;化合物 FRAKEFAMIDE |
| 英文名稱 | FRAKEFAMIDE |
| 英文同義詞 | FRAKEFAMIDE;L-Tyrosyl-D-alanyl-L-(4-fluoro)phenylalanyl-L-phenylalanylamide;L-Phenylalaninamide, L-tyrosyl-D-alanyl-4-fluoro-L-phenylalanyl- |
| CAS號(hào) | 188196-22-7 |
| 分子式 | C30H34FN5O5 |
| 分子量 | 563.62 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 188196-22-7.mol |
| 結(jié)構(gòu)式 |  |
FRAKEFAMIDE 性質(zhì)
| 沸點(diǎn) | 973.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.295±0.06 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 9.97±0.15(Predicted) |
| 序列 | Tyr-Ala-Phe(4-F)-Phe-NH2 |
Frakefamide 具有有效的止痛作用，是選擇性的 μ受體的外圍激動(dòng)劑。Frakefamide 不能透過(guò)血腦屏障，進(jìn)入中樞神經(jīng)系統(tǒng)。
Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg.