STAT5 Inhibitor
| 中文名稱 | STAT5 Inhibitor |
|---|---|
| 中文同義詞 | STAT5抑制劑(STAT5-IN-1);STAT5抑制劑;化合物STAT5 INHIBITOR;N'-((4-氧代-4H-苯并吡喃-3-基)亞甲基)煙肼;優(yōu)選]STAT5 INHIBITOR;化合物STAT5 INHIBITOR,10 MM DMSO 溶液;STAT5-IN-1(MDK-6314) |CAS 285986-31-4;STAT5-IN-1 ,S6784 |
| 英文名稱 | STAT5 Inhibitor |
| 英文同義詞 | STAT5-IN-1;N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT5 Inhibitor;CS-2509;STAT5 Inhibitor 1;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;MDK6314;3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide |
| CAS號 | 285986-31-4 |
| 分子式 | C16H11N3O3 |
| 分子量 | 293.28 |
| EINECS號 | 604-604-1 |
| 相關(guān)類別 | 細(xì)胞生物學(xué)試劑 |
| Mol文件 | 285986-31-4.mol |
| 結(jié)構(gòu)式 |  |
STAT5 Inhibitor 性質(zhì)
| 熔點(diǎn) | 214-216 °C |
|---|---|
| 密度 | 1.33±0.1 g/cm3(Predicted) |
| 儲存條件 | 2-8°C(protect from light) |
| 溶解度 | DMSO 中≥9.58 mg/mL；不溶于乙醇；不溶于水 |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 10.44±0.46(Predicted) |
| 顏色 | 白色至淺黃色 |
| InChI | InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21) |
| InChIKey | DAVIKTBRCQWOGT-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1C(NN=CC1C(=O)C2=CC=CC=C2OC=1)=O |
STAT5-IN-1 是一種有效的選擇性 STAT5 抑制劑，其對于STAT5β亞型的IC50值為47 μM。
| Target | Value |
|
STAT5β
(Cell-free assay) | 47 μM |
The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101853 | STAT5 Inhibitor STAT5-IN-1 | 285986-31-4 | 5mg | 550元 |
| 2026/06/05 | HY-101853 | STAT5 Inhibitor STAT5-IN-1 | 285986-31-4 | 10mM * 1mLin DMSO | 605元 |