607736-84-5
| 中文名稱 | 607736-84-5 |
|---|---|
| 中文同義詞 | 化合物 T13040;化合物 SUN 1334H |
| 英文名稱 | SUN 1334H |
| 英文同義詞 | SUN 1334H;2-?[[(2E)?-?4-?[4-?[bis(4-?Fluorophenyl)?methyl]?-?1-?piperazinyl]?-?2-?buten-?1-?yl]?oxy]?-acetic acid hydrochloride |
| CAS號 | 607736-84-5 |
| 分子式 | C23H27ClF2N2O3 |
| 分子量 | 452.93 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 607736-84-5.mol |
| 結構式 |  |
607736-84-5 性質
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
Ki: 9.7 nM (H1 receptor)
SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K + -currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects.
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-U00084 | 607736-84-5 SUN 1334H | 607736-84-5 | 1mg | 1000元 |