4-氨基己-5-烯酸
| 中文名稱 | 4-氨基己-5-烯酸 |
|---|---|
| 中文同義詞 | 4-氨基己-5-烯酸;氨己烯酸雜質;維加巴林;Vigabatrin試劑;Vigabatrin試劑;13C,氘5-消旋-維加巴特林鹽酸鹽 |
| 英文名稱 | (±)-4-aminohex-5-enoic acid |
| 英文同義詞 | (±)-4-aminohex-5-enoic acid;CPP 109;5-Hexenoic acid, 4-amino-;SABRIL; Γ-VINYL-GABA;rac-VigabatrinDiscontinued See V253010;(+/-)-Vigabatrin;Vigabatrin, racemic mixture;Vigabatrin hydrochloride salt, racemic mixture |
| CAS號 | 68506-86-5 |
| 分子式 | C6H11NO2 |
| 分子量 | 129.16 |
| EINECS號 | 270-929-6 |
| 相關類別 | 離子通道;膜轉運 |
| Mol文件 | 68506-86-5.mol |
| 結構式 |  |
4-氨基己-5-烯酸 性質
| 熔點 | 209℃ |
|---|---|
| 沸點 | 277.7±28.0 °C(Predicted) |
| 密度 | 1.064±0.06 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 酸度系數(shù)(pKa) | 4.36±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 米白色 |
| 水溶解性 | Soluble to 100 mM in water |
| 主要應用 | pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) |
| InChIKey | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| SMILES | NC(CCC(O)=O)C=C |
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.
安全信息
| 危險品標志 | Xi |
|---|---|
| 危險類別碼 | 36/37/38 |
| 安全說明 | 26-36 |
| WGK Germany | 3 |
| RTECS號 | MP7745000 |
| 海關編碼 | 2922498050 |
| 存儲類別 | 6.1C - 可燃，急性毒性 類別3 毒性化合物或者引起慢性影響的化合物 |
| 危險性類別 | 特異性靶器官毒性-反復接觸類別1 |
| 毒害物質數(shù)據(jù) | 68506-86-5(Hazardous Substances Data) |
| 毒性 | LD50 oral in rat: 3gm/kg |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-15399R | 4-氨基己-5-烯酸 Vigabatrin (Standard) | 68506-86-5 | 5 mg | 1250元 |
| 2026/06/05 | HY-15399R | 4-氨基己-5-烯酸 Vigabatrin (Standard) | 68506-86-5 | 10 mg | 2000元 |