ASOXIME CHLORIDE
| 中文名稱 | ASOXIME CHLORIDE |
|---|---|
| 中文同義詞 | 化合物 T14333;化合物ASOXIME DICHLORIDE;氯化阿索肟;1-[[[4-(氨基羰基)吡啶鎓]甲氧基]甲基]-2-[(羥基亞氨基)甲基]吡啶鎓 二氯化物;嗨6氯化物 |
| 英文名稱 | ASOXIME CHLORIDE |
| 英文同義詞 | HI 6 Chloride;1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride;4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride;Transant;(((4-(iminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridi;4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-pyridinium-dichloride-2-oxime;hi6;hi-6dichloride |
| CAS號 | 34433-31-3 |
| 分子式 | C14H16Cl2N4O3 |
| 分子量 | 359.21 |
| EINECS號 | |
| 相關(guān)類別 | Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles |
| Mol文件 | 34433-31-3.mol |
| 結(jié)構(gòu)式 |  |
ASOXIME CHLORIDE 性質(zhì)
| 熔點 | 145-147°C |
|---|---|
| 儲存條件 | -20°C |
| 溶解度 | 在水中的溶解度為15mg/mL（澄清溶液） |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 水溶解性 | H2O: 15mg/mL (clear solution) |
| 穩(wěn)定性 | 1-10%水溶液 |
| InChI | 1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H |
| InChIKey | QELSIJXWEROXOE-UHFFFAOYSA-N |
| SMILES | [Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1 |
Asoxime dichloride 是乙酰膽堿受體 (AChRs) 拮抗劑，包括煙堿受體，α7 乙酰膽堿受體。Asoxime dichloride 參與調(diào)節(jié)免疫應(yīng)答。Asoxime dichloride 可作為抗原使用，改善神經(jīng)系統(tǒng)的免疫效果。
IC50: acetylcholine receptors (AChRs)
Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1?mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant.
| Animal Model: | Balb/c mice |
| Dosage: | 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg |
| Administration: | Intramuscular injection into the rear limb |
| Result: | Improved vaccination efficacy at the level of immunity regulation by the nervous system. |
安全信息
| WGK Germany | 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |