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(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚

(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚

中文名稱(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚
中文同義詞(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚;束骨姜黃醇;黃根醇;XANTHORRHIZOL,ANTIOXIDANT AGENT;黃藥唑;黃藥醇
英文名稱XANTHORRHIZOL
英文同義詞XANTHORRHIZOL;5-(1,5-Dimethyl-4-hexenyl)-2-methylphenol;o-Cresol, 5-(1,5-dimethyl-4-hexenyl)-, (-)-;Phenol, 5-(1,5-dimethyl-4-hexenyl)-2-methyl-, (R)-;(R)-5-(1,5-dimethyl-4-hexenyl)-o-cresol;Xanthorrhizol from Cucuma xanthorrhiza;(R)-Xanthorrizol;2-Methyl-5-[(R)-1,5-dimethyl-4-hexenyl]phenol
CAS號(hào)30199-26-9
分子式C15H22O
分子量218.33
EINECS號(hào)250-090-2
相關(guān)類別
Mol文件30199-26-9.mol
結(jié)構(gòu)式(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚 結(jié)構(gòu)式

(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚 性質(zhì)

沸點(diǎn)326.9±11.0 °C(Predicted)
密度0.948±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度可溶于氯仿(少許)、乙酸乙酯(少許)、甲醇(少許)
形態(tài)無(wú)色至淡黃色油狀物。
酸度系數(shù)(pKa)10.34±0.10(Predicted)
顏色淡黃色至淺黃色
化妝品成分功效ANTI-SEBUM
LogP5.480

(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚 用途與合成方法

Xanthorrhizol 是從 Curcuma xanthorrhiza 中分離出來(lái)的,一種有效的抗菌劑。

Xanthorrhizol is a potential antibacterial agent from Curcuma xanthorrhiza against streptocpccus mutants. SEM analysis shows that, treatment of Candida species with MIC of Xanthorrhizol affects the external morphology of these yeasts. Cells incubated in the presence of Xanthorrhizol demonstrate a greater tendency to clump compared with the control cultures. Xanthorrhizol treated C. glabrata cells shows minor abnormalities without a smooth or a slightly awkward surface. Xanthorrhizol-treated Candida cells exhibit deformation and protrusions on the cell surface, which is more clearly demonstrated with C. guilliermondii and C. parapsilosis . In general, Candida exposed to, Xanthorrhizol at concentrations 1 x MICs exhibits substantial ultrastructural abnormalities such as shape deformation, protrusion, rugged cells surface, and clumping.

Ear edema induced by the topical application of TPA is suppressed by pre-treatment with Xanthorrhizol in a doserelated manner (P<0.005). Topical application of Xanthorrhizol alone does not induce ear edema in mice. All the mice treated with 7.5 nM TPA for 19 weeks after initiation by DMBA developed an average of 15.5±2.3 skin tumors per mouse (tumor multiplicity). Pre-treatment with 2 and 6 μM Xanthorrhizol reduces tumor multiplicity to 6.9±1.1 (P<0.005) and 4.0±1.1 (P<0.005), respectively, at 19 weeks. In addition, Xanthorrhizol at 2 and 6 μM dose dependently lowers the percentage of tumor-bearing mice (tumor incidence) to 80 and 57%, respectively, at the termination of the experiments. Furthermore, the tumor multiplicity (P<0.05) and incidence are reduced in the DMBA-initiated mice that are topically treated with Xanthorrhizol for 6 weeks after the induction of papillomas with hyperplasia, mild dysplasia and moderate dysplasia by topical TPA application for 6, 18 and 24 weeks, respectively. The increased ODC expression in mouse epidermis with acute inflammation and tumor promotion induced by TPA is inhibited by pre-treatment with Xanthorrhizol in a dose-dependent manner. The topical application of Xanthorrhizol after the induction of papillomas with hyperplasia and dysplasia also potently inhibited ODC expression.

安全信息

危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼60
安全說(shuō)明53-36/37/39-45

MSDS信息

(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚 上下游產(chǎn)品信息

"(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚"相關(guān)產(chǎn)品信息
葉黃素 L-木酮糖 D-[2-2H]XYLOSE 3-(4-嗎啉)-1-丙醇 UDP-D-木糖 4-[(1R)-1,5-Dimethyl-4-hexen-1-yl]-2-cyclohexen-1-one 5-[(1R)-1,5-Dimethyl-4-hexen-1-yl]-2-methyl-3-cyclohexene-1,1-diol 7-ACETYLLYCOPSAMINE 4-[(1R)-1,5-Dimethyl-4-hexen-1-yl]-6-hydroxy-2-cycloehexen-1-one 2-脫氧-D-蘇式戊糖 花椒毒酚 (R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚
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