化合物 T16947
| 中文名稱 | 化合物 T16947 |
|---|---|
| 中文同義詞 | 化合物 T16947;化合物SU16F;SU 16F,PDGFRΒ抑制劑;化合物SU16F,10 MM DMSO 溶液;SU16f試劑;SU16f試劑;5-[(1,2-二氫-2-氧代-6-苯基-3H-吲哚-3-亞基)甲基]-2,4-二甲基-1H-吡咯-3-丙酸 |
| 英文名稱 | SU 16f |
| 英文同義詞 | 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-;3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid;SU16f, 10 mM in DMSO;PDGFR Tyrosine Kinase Inhibitor VII |
| CAS號(hào) | 251356-45-3 |
| 分子式 | C24H22N2O3 |
| 分子量 | 386.44 |
| EINECS號(hào) | |
| 相關(guān)類別 | Angiogenesis and Metastasis |
| Mol文件 | 251356-45-3.mol |
| 結(jié)構(gòu)式 |  |
化合物 T16947 性質(zhì)
| 沸點(diǎn) | 661.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.292±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at RT |
| 溶解度 | 在 DMSO 中溶解度為 100 mM |
| 形態(tài) | 暗橙色固體 |
| 酸度系數(shù)(pKa) | 4+-.0.10(Predicted) |
| 顏色 | 黃至橙色 |
| InChI | 1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13- |
| InChIKey | APYYTEJNOZQZNA-MOSHPQCFSA-N |
|
PDGFRβ 10 nM (IC 50 ) |
PDGFR2 140 nM (IC 50 ) |
PDGFR1 2.29 μM (IC 50 ) |
SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .
Cell Proliferation Assay
| Cell Line: | SGC-7901 cells in GC-MSC/SGC-7901 co-culture system |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. |
Western Blot Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. |
安全信息
| WGK Germany | WGK 1 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 1 mg | 480元 |
| 2026/06/05 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 5mg | 980元 |