PD 404182
| 中文名稱 | PD 404182 |
|---|---|
| 中文同義詞 | 化合物 T28348;PD404182|||PD-404182;化合物 PD 404182 |
| 英文名稱 | PD 404182 |
| 英文同義詞 | 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE;PD 404,182;3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro- |
| CAS號(hào) | 72596-74-8 |
| 分子式 | C11H11N3S |
| 分子量 | 217.29 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
PD 404182 性質(zhì)
| 沸點(diǎn) | 366.8±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.43±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | DMSO：≥22 mg/mL |
| 酸度系數(shù)(pKa) | 6.27±0.20(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 淺黃至黃色 |
PD 404182 是一種有效的、競(jìng)爭(zhēng)性的人類二甲基精氨酸二甲基氨基水解酶 1 (DDAH1) 抑制劑，IC50 值為 9 μM。PD 404182 在體外表現(xiàn)出抗血管生成和抗病毒活性。
IC50: 9 μM (DDAH1)
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC
50
of 1 μM.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD
4+
T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
Cell Viability Assay
| Cell Line: | Human dermal microvascular endothelial cells (ECs) |
| Concentration: | 10-300 μM |
| Incubation Time: | 24 hours |
| Result: | Did not induce cytotoxicity. |
| 提供商 | 語(yǔ)言 |
|---|---|
|
英文
|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-16958 | PD 404182 PD 404182 | 72596-74-8 | 5mg | 1850元 |
| 2026/06/05 | HY-16958 | PD 404182 | 72596-74-8 | 10 mM * 1 mLin DMSO | 2035元 |