葫蘆巴堿
| 中文名稱 | 葫蘆巴堿 |
|---|---|
| 中文同義詞 | 葫蘆巴鹼;菸鹼酸N-甲內(nèi)鹽;N-甲菸鹼酸內(nèi)鹽;煙酸甜菜堿;葫蘆巴堿;1-甲基吡啶鎓-3-甲酸內(nèi)鹽;1-甲基吡啶-3-甲酸內(nèi)鹽;葫蘆巴堿, 來源于葫蘆巴 |
| 英文名稱 | Trigonelline |
| 英文同義詞 | 1-Methylpyridinium-3-carboxylate;Gynesis;N-Methylnicotinic betaine;betainnicotinate;Coffearin;Coffearine;n’-methylnicotinicacid;Nicotinic acid N-methylbetaine |
| CAS號(hào) | 535-83-1 |
| 分子式 | C7H7NO2 |
| 分子量 | 137.14 |
| EINECS號(hào) | 208-620-5 |
| 植物來源 | 葫蘆巴 |
| 相關(guān)類別 | 小分子抑制劑;對(duì)照品;小分子抑制劑，天然產(chǎn)物;中藥對(duì)照品;標(biāo)準(zhǔn)品;對(duì)照品,標(biāo)準(zhǔn)品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;分析對(duì)照品;分析試劑標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)提取物;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;其他原料;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對(duì)照品;食品原料;通用生化試劑-有機(jī)酸;標(biāo)準(zhǔn)提取物;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors |
| Mol文件 | 535-83-1.mol |
| 結(jié)構(gòu)式 |  |
葫蘆巴堿 性質(zhì)
| 熔點(diǎn) | 260°C (dec.) |
|---|---|
| 沸點(diǎn) | 251.96°C (rough estimate) |
| 密度 | 1.2528 (rough estimate) |
| 折射率 | 1.5030 (estimate) |
| 儲(chǔ)存條件 | Refrigerator |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形態(tài) | 固體 |
| 顏色 | 灰白色至淺米色 |
| 主要應(yīng)用 | pharmaceutical (small molecule) |
| InChI | InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3 |
| InChIKey | WWNNZCOKKKDOPX-UHFFFAOYSA-N |
| SMILES | C1(C([O-])=O)=CC=C[N+](C)=C1 |
| LogP | -3.910 (est) |
| Target | Value |
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PLCγ1
() | |
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PI3K
() | |
|
Akt
() | |
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microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
藥理藥效:為胡蘆巴中的主要成分，具有抗腫瘤作用。
安全信息
| 安全說明 | 24/25 |
|---|---|
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| 海關(guān)編碼 | 29339900 |
| 存儲(chǔ)類別 | 13 - 不可燃性固體 |
| 毒害物質(zhì)數(shù)據(jù) | 535-83-1(Hazardous Substances Data) |