STING AGONIST-4
| 中文名稱 | STING AGONIST-4 |
|---|---|
| 中文同義詞 | 化合物STING AGONIST-4;化合物STING AGONIST-4,10 MM DMSO 溶液 |
| 英文名稱 | 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- |
| 英文同義詞 | 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-;STING agonist-4;TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA;diABZI STING Agonist-2;1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI);1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide;1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide;STING agonist-4, 10 mM in DMSO |
| CAS號(hào) | 2138300-40-8 |
| 分子式 | C34H38N12O4 |
| 分子量 | 678.74 |
| EINECS號(hào) | |
| 相關(guān)類別 | 活性分子;普通化學(xué)品 |
| Mol文件 | 2138300-40-8.mol |
| 結(jié)構(gòu)式 |  |
STING AGONIST-4 性質(zhì)
| 密度 | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | DMSO：微溶 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 11.97±0.43(Predicted) |
| 顏色 | 白色至灰色 |
| InChIKey | ICZSAXDKFXTSGL-UHFFFAOYSA-N |
| SMILES | C(N1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21)CCCN1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21 |
IC50: 20 nM (STING agonist-4)
STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC 50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K d ) of approximately 1.6 nM. STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC 50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.
Cell Viability Assay
| Cell Line: | Human peripheral blood mononuclear cells (PBMCs) |
| Concentration: | 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM |
| Incubation Time: | 2 hours |
| Result: | Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-123943 | STING agonist-4 | 2138300-40-8 | 1 mg | 1600元 |
| 2026/06/05 | HY-123943 | STING AGONIST-4 STING agonist-4 | 2138300-40-8 | 5mg | 3500元 |