色酚 AS-E
| 中文名稱 | 色酚 AS-E |
|---|---|
| 中文同義詞 | 2-羥基-N-(4氯基苯基)-3-萘甲酰胺;N-(3-羥基-2-萘甲?；?對氯苯胺;色酚 AS-E;冰染偶合組分 10;4'-氯-3-羥基-2-萘苯胺;納夫妥AS-E;萘酚AS-E;C.I.冰染偶合組分10 |
| 英文名稱 | Naphthol AS-E |
| 英文同義詞 | NAPHTHOL AS-E;NAPTHOL AS-E;N-(4-CHLOROPHENYL)-3-HYDROXY-2-NAPHTHAMIDE;c.i. azoic coupling component 10;AZOIC COUPLING COMPONENT 10;AcnaNaphtholPC;DaitoGrounderE;n-(4-chlorophenyl)-3-hydroxy-2-naphthalenecarboxamid |
| CAS號 | 92-78-4 |
| 分子式 | C17H12ClNO2 |
| 分子量 | 297.74 |
| EINECS號 | 202-189-7 |
| 相關(guān)類別 | 冰染染料;染料;苯酚;色酚;原料;化工原料;染料中間體;Intermediates of Dyes and Pigments;Substrates;醫(yī)藥原料 |
| Mol文件 | 92-78-4.mol |
| 結(jié)構(gòu)式 |  |
色酚 AS-E 性質(zhì)
| 熔點 | 255°C |
|---|---|
| 沸點 | 416.5±30.0 °C(Predicted) |
| 密度 | 1.399±0.06 g/cm3(Predicted) |
| 蒸氣壓 | 0Pa at 25℃ |
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于二甲基甲酰胺 |
| 形態(tài) | 米色固體 |
| 酸度系數(shù)(pKa) | 8.69±0.40(Predicted) |
| 色指數(shù) | 37510 |
| 顏色 | 白色至淡黃色至深綠色 |
| LogP | 2.97 at 23℃ and pH7.2 |
| CAS 數(shù)據(jù)庫 | 92-78-4(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy- (92-78-4) |
|
KIX-KID 2.26 μM (IC 50 ) |
CREB (cyclic AMP-response element-binding protein) is a downstream transcription factor of a multitude of signaling pathways emanating from receptor tyrosine kinases or G-protein coupled receptors.CREB can not be activated until it is phosphorylated at Ser133 and its subsequent binding to CREB-binding protein (CBP) through the kinase-inducible domain (KID) in CREB and KID-interacting (KIX) domain in CBP.In a cell-based CREB Renilla luciferase reporter assay, Naphthol AS-E?inhibits CREB-mediated gene transcription with an IC 50 of 2.29 μM. In HEK293T-based complementation assay, Naphthol AS-E?dose-dependently inhibited Renilla luciferase activity with an IC 50 of 2.9 μM by directly binding to CBP's KIX domain (K d ~8.6 μM using a recombinant KIX).Naphthol AS-E?exhibits low μM activity in inhibiting the proliferation of all these cancer cells, which is consistent with its cellular CREB inhibition potency. The average GI 50 values for A549, MCF-7, MDA-MB-231 and MDA-MB-468 are approximately?2.9μM, 2.81μM, 2.35μM and 1.46μM, respectively.Naphthol AS-E (2.5 μM-10 μM; 48 hours) decreases the expression of anti-apoptotic protein Bcl-2. The expression of VEGF is also decreased.
安全信息
| TSCA | TSCA listed |
|---|---|
| 海關(guān)編碼 | 2924.29.7790 |