5-(十四烷基氧)-2-糠酸
| 中文名稱 | 5-(十四烷基氧)-2-糠酸 |
|---|---|
| 中文同義詞 | 5-(十四烷基氧)-2-糠酸;5-(十四烷氧基)-2-糠酸;化合物TOFA;5-(十四氧基)呋喃-2-甲酸;5-四巰基呋喃-2-羧酸(TOFA);TOFA (5-(TETRADECYLOXY)-2-FUROIC ACID),ACETYL-COA CARBOXYLASE抑制劑.;化合物TOFA,10 MM DMSO 溶液;乙酰輔酶A羧化酶-Α(ACCA)變構(gòu)抑制劑(TOFA) |
| 英文名稱 | 5-(TETRADECYLOXY)-2-FUROIC ACID |
| 英文同義詞 | 5-(tetradecyloxy)-2-furancarboxylicaci;5-tetradecyloxy-2-furonicacid;mdl14514;RMI-14514;TOFA (5-(Tetradecyloxy)-2-furoic acid);5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID;5-(TETRADECYLOXY)-2-FUROIC ACID;2-Furancarboxylic acid,5-(tetradecyloxy)- |
| CAS號(hào) | 54857-86-2 |
| 分子式 | C19H32O4 |
| 分子量 | 324.45 |
| EINECS號(hào) | |
| 相關(guān)類別 | 細(xì)胞生物學(xué)試劑;其它;對(duì)照品 |
| Mol文件 | 54857-86-2.mol |
| 結(jié)構(gòu)式 | ![]() |
5-(十四烷基氧)-2-糠酸 性質(zhì)
| 熔點(diǎn) | 112-115 °C |
|---|---|
| 沸點(diǎn) | 441.7±25.0 °C(Predicted) |
| 密度 | 1.003±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 二甲基亞砜:2.5 mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 3.55±0.10(Predicted) |
| 顏色 | 白色至米色 |
| 穩(wěn)定性 | 可在-20°下的DMSO或乙醇溶液保存長(zhǎng)達(dá)1個(gè)月。 |
| InChI | 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21) |
| InChIKey | CZRCFAOMWRAFIC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O |
| Target | Value |
|
ACCA
() |
TOFA (5-tetradecyloxy-2-furoic acid) is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and HCT-15, with an IC 50 at approximately 5.0, 5.0, and 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis and induces cell death in a dose-dependent manner. TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC 50 values of ~26.1 and 11.6 μg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time and dose dependent manner, arrests the cells in the G0/G1 cell cycle phase and induces apoptosis. Acetyl-CoA-carboxylase-α (ACCA) is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis and induces caspase activation and cell death in most PCa cell lines.
TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi?cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm 3 . No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy.
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS號(hào) | LU0288000 |
| 海關(guān)編碼 | 29321900 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 提供商 | 語(yǔ)言 |
|---|---|
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英文
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/03/03 | S6690 | 5-(十四烷基氧)-2-糠酸 TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | 5mg | 794.43元 |
| 2026/03/03 | S6690 | 5-(十四烷基氧)-2-糠酸 TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | 10mM (1mL in DMSO) | 958.23元 |
