N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺
| 中文名稱 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 |
|---|---|
| 中文同義詞 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺;N-(4-甲氧基苯基)-1-苯基-1H-吡唑-3-胺;N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺,10 MM DMSO 溶液 |
| 英文名稱 | FPL 62064 |
| 英文同義詞 | 1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;FPL 62064;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2;FPL 62064, 10 mM in DMSO |
| CAS號 | 103141-09-9 |
| 分子式 | C16H15N3O |
| 分子量 | 265.31 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 103141-09-9.mol |
| 結構式 |  |
N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 性質(zhì)
| 沸點 | 442.6±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 儲存條件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 二甲基亞砜：250 mg/mL（942.29 mM） |
| 酸度系數(shù)(pKa) | 2.42±0.50(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
| 化妝品成分功效 | ANTI-SEBUM |
| Target | Value |
|
seminal vesicle prostaglandin synthetase
(Cell-free assay) | 3.1 μM |
|
RBL-1 cytosolic 5-LOX
(Cell-free assay) | 3.5 μM |
FPL 62064 inhibits both 5-1ipoxygenase (IC 50 of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC 50 of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC 50 of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC 50 of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC 50 s for leukotriene (IC 50 of 0.72 μM) and prostaglandin (IC 50 of 0.43 μM) production are similar.
FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex.
| Animal Model: | Female LACA mice (20-30 g) injected with immune complex. |
| Dosage: | 5 mg/kg, 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a dose-related inhibition of dye extravasation, leukotriene C 4 (LTC 4 ) and prostaglandin E 2 (PGE 2 ) formation. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-105024 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064 | 103141-09-9 | 1 mg | 571元 |
| 2026/06/05 | HY-105024 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064 | 103141-09-9 | 5mg | 1500元 |