辛伐他汀EP雜質(zhì)A
| 中文名稱 | 辛伐他汀EP雜質(zhì)A |
|---|---|
| 中文同義詞 | 辛伐他汀酸;化合物 T24865;辛伐他汀酸(替尼伐他汀);替伐他汀 |
| 英文名稱 | simvastatin acid |
| 英文同義詞 | (3R,5R)-3,5-Dihydroxy-7-[(1S)-1-(2,2-dimethylbutyryloxy)-3β,7α-dimethyl-1,2,3,7,8,8aα-hexahydronaphthalene-8α-yl]heptanoic acid;(βR,δR,1S)-8α-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8aβ-hexahydro-β,δ-dihydroxy-2β,6α-dimethyl-1β-naphthaleneheptanoic acid;2,2-Dimethylbutanoic acid [(1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]naphthalen]-1β-yl ester;2,2-Dimethylbutyric acid (1S)-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]-1,2,3,7,8,8aα-hexahydronaphthalene-1β-yl ester;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid;1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, (βR,δR,1S,2S,6R,8S,8aR)-;(3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-di methyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptan oic acid;Simvastatin Acid D6Q: What is Simvastatin Acid D6 Q: What is the CAS Number of Simvastatin Acid D6 |
| CAS號 | 121009-77-6 |
| 分子式 | C25H40O6 |
| 分子量 | 436.585 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 121009-77-6.mol |
| 結(jié)構(gòu)式 |  |
辛伐他汀EP雜質(zhì)A 性質(zhì)
| 沸點 | 607.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.13±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 4.31±0.10(Predicted) |
| EPA化學(xué)物質(zhì)信息 | 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-, (?R,?R,1S,2S,6R,8S,8aR)- (121009-77-6) |
辛伐他汀EP雜質(zhì)A 的水解產(chǎn)物，是一種有效的 HMG-CoA 還原酶 (HMGCR) 抑制劑。Simvastatin acid 降低吲哚酚硫酸鹽 (Indoxyl sulfate) 介導(dǎo)的活性氧 (ROS) 產(chǎn)生。Simvastatin acid 也可調(diào)節(jié)心肌細胞和轉(zhuǎn)染 OATP3A1 基因的 HEK293 細胞的 OATP3A1 表達。
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-119695 | 辛伐他汀EP雜質(zhì)A Simvastatin acid | 121009-77-6 | 1 mg | 2350元 |
| 2026/06/05 | HY-119695 | 辛伐他汀EP雜質(zhì)A Simvastatin acid | 121009-77-6 | 5 mg | 5630元 |