棕矢車菊素
| 中文名稱 | 棕矢車菊素 |
|---|---|
| 中文同義詞 | 爵篩奧素;棕矢車菊素;棕矢車菊素、合金歡素;4',5,7-三羥基-3',6-二甲氧基苯并吡喃-4-酮;4',5,7-三羥基-3',6-二甲氧基黃酮;合金歡素;棕矢車菊素(合金歡素,爵篩奧素);棕矢車菊素(標準品) |
| 英文名稱 | Jaceosidin |
| 英文同義詞 | JACEOSIDIN;3',6-Dimethoxy-4',5,7-trihydroxyflavone;5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;6-Hydroxyluteolin 3',6-dimethyl ether;Jacesiolin;4',5,7-Trihydroxy-3',6-dimethoxyflavone;4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-;5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one |
| CAS號 | 18085-97-7 |
| 分子式 | C17H14O7 |
| 分子量 | 330.29 |
| EINECS號 | |
| 植物來源 | 艾葉 |
| 相關類別 | 天然產物;植物提取物;中藥對照品;標準品;對照品;醫(yī)藥中間體;分析試劑標準品;標準品-中藥標準品;標準品-對照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;黃酮;標準品 -中藥標準品;標準品，對照品;新品推薦 |
| Mol文件 | 18085-97-7.mol |
| 結構式 |  |
棕矢車菊素 性質
| 熔點 | 259-260 °C |
|---|---|
| 沸點 | 619.0±55.0 °C(Predicted) |
| 密度 | 1.483±0.06 g/cm3(Predicted) |
| 儲存條件 | 2-8°C(protect from light) |
| 溶解度 | 可溶于DMSO（輕微）、甲醇（輕微、超聲處理）、吡啶（輕微） |
| 形態(tài) | 固體 |
| 酸度系數(pKa) | 6.47±0.40(Predicted) |
| 顏色 | 淡黃色至淺黃色 |
| 穩(wěn)定性 | 吸濕性 |
| 主要應用 | 食品和飲料 |
| InChI | InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3 |
| InChIKey | GLAAQZFBFGEBPS-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 |
| LogP | 1.300 (est) |
從艾葉中分離得到的棕矢車菊素和異澤蘭黃素屬于環(huán)烯醚萜苷類，其主要具有清熱、鎮(zhèn)痛等相關活性作用。
|
Bax
|
COX-2
|
Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells.
Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation.
Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity.
Jaceosidin shows cytostatic activity to HES and HESC cells with IC
50
s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC
50
, 70.54, 147.14 μM, respectively), after treatment for 48 h.
Cell Viability Assay
| Cell Line: | Hec1A, KLE, HES and HESC cells |
| Concentration: | 3.125, 6.25, 12.5, 25, 50, and 100 μM |
| Incubation Time: | 48 hour |
| Result: | Showed cytostatic activity to HES and HESC cells with IC 50 s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC 50 , 70.54, 147.14 μM). |
Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice.
Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice.
Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats.
| Animal Model: | 5-week-old male BALB/c mice (23-26 g) |
| Dosage: | 10 and 20 mg/kg |
| Administration: | P.O. once a day for 3 days |
| Result: | Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation. |
| Animal Model: | Male Sprague-Dawley rats (180-200 g) |
| Dosage: | 20 mg/kg |
| Administration: | P.O., for 2 hour |
| Result: | Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively. |
藥理藥效:抗腫瘤，抗氧化、清除氧自由基。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0931 | 棕矢車菊素 Jaceosidin | 18085-97-7 | 1mg | 1793.61元 |
| 2026/06/05 | HY-N0831 | 棕矢車菊素 Jaceosidin | 18085-97-7 | 1mg | 600元 |