L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
| 中文名稱 | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE |
|---|---|
| 中文同義詞 | 化合物 T25749; |
| 英文名稱 | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE |
| 英文同義詞 | L-NIL HCL;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE;L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2);L-Lysine ω-acetamidine dihydrochloride;L-NIL DIHYDROCHLORIDE |
| CAS號 | 159190-45-1 |
| 分子式 | C8H18ClN3O2 |
| 分子量 | 223.7 |
| EINECS號 | |
| 相關(guān)類別 | Nitric Oxide |
| Mol文件 | 159190-45-1.mol |
| 結(jié)構(gòu)式 |  |
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE 性質(zhì)
| 儲存條件 | -20°C |
|---|---|
| 溶解度 | DMF：15mg/mL；二甲基亞砜：15mg/mL；乙醇：1mg/mL； PBS：30mg/mL；水：50mg/mL |
| 形態(tài) | 白色至類白色固體。 |
| 生物來源 | synthetic (organic) |
| 水溶解性 | water: 50mg/mL, clear, colorless |
| InChI | 1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1 |
| InChIKey | OQIBCXRAFAHXMM-KLXURFKVSA-N |
| SMILES | Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O |
L-NIL dihydrochloride 是誘導(dǎo)型一氧化氮合成酶 (iNOS) 的抑制劑，其對 miNOS 的 IC50 值為3.3 μM。
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.
| Animal Model: | Adult male Balb/c (20-25 g). |
| Dosage: | 10 and 30?mg/kg. |
| Administration: | Intraperitoneally at the end of CLP and at 6?h after sepsis induction. |
| Result: |
Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle. |
安全信息
| 危險(xiǎn)品標(biāo)志 | Xi |
|---|---|
| 危險(xiǎn)類別碼 | 36/37/38 |
| 安全說明 | 37/39-26-36 |
| WGK Germany | 3 |
| 存儲類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 眼部刺激 類別2 經(jīng)皮刺激 類別2 特異性靶器官毒性-一次接觸，類別3 |
| 提供商 | 語言 |
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英文
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