四氫氨基吖啶
| 中文名稱 | 四氫氨基吖啶 |
|---|---|
| 中文同義詞 | 9-氨基-1,2,3,4-四氫吖啶 鹽酸鹽;鹽酸他克林(四氫氨基吖啶);四氫氨基吖啶;塔克林;9-氨基-1,2,3,4-四氫吖啶鹽酸鹽水合物;鹽酸他克林;鹽酸單滿吖啶氨;9-氨基-1,2,3,4-四氫吖啶鹽酸 |
| 英文名稱 | TACRINE HYDROCHLORIDE |
| 英文同義詞 | 1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride;1,2,3,4-tetrahydro-9-aminoacridinehydrochloride;1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride;9-amino-1,2,3,4-tetrahydro-acridinhydrochloride;1,2,3,4-TETRAHYDRO-9-ACRYDINAMINEHCLMONOHYDRATE;1,2,3,4-TETRAHYDRO-9-ACRIDINAMINEHYDROCHLORIDEMONOHYDRATE;1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate;9-Amino-1,2,3,4-tetrahydroacridine, Hydrochloride Dihydrate |
| CAS號 | 1684-40-8 |
| 分子式 | C13H15ClN2 |
| 分子量 | 234.72 |
| EINECS號 | 216-867-5 |
| 相關類別 | 合成;醫(yī)藥中間體;材料化學;醫(yī)藥;COGNEX;Chemical Amines;Amines;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Acetylcholine receptor |
| Mol文件 | 1684-40-8.mol |
| 結構式 |  |
四氫氨基吖啶 性質
| 熔點 | 280-284 °C(lit.) |
|---|---|
| 儲存條件 | Inert atmosphere,2-8°C |
| 溶解度 | 溶于水性緩沖液 |
| 酸度系數(shù)(pKa) | pKa 9.8 (Uncertain) |
| 形態(tài) | 結晶固體 |
| 顏色 | 白色至淺黃色 |
| InChI | InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H |
| InChIKey | ZUFVXZVXEJHHBN-UHFFFAOYSA-N |
| SMILES | C12=CC=CC=C1C(N)=C1CCCCC1=N2.Cl |
| CAS 數(shù)據(jù)庫 | 1684-40-8(CAS DataBase Reference) |
| EPA化學物質信息 | Tacrine hydrochloride (1684-40-8) |
| Target | Value |
|
BChE
(Cell-free assay) | 25.6 nM |
|
AChE
(Cell-free assay) | 31 nM |
Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner.
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC
50
of ~500 μM.
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC
50
of ~190 μM at -60 mV.
Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice.
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice.
安全信息
| 危險品標志 | T,Xn |
|---|---|
| 危險類別碼 | 25-36/37/38-20/22 |
| 安全說明 | 26-36-45 |
| 危險品運輸編號 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS號 | AR9532500 |
| 危險等級 | 6.1(a) |
| 包裝類別 | II |
| 毒性 | LD50 intravenous in mouse: 5600ug/kg |