西奧骨化醇
| 中文名稱 | 西奧骨化醇 |
|---|---|
| 中文同義詞 | 西奧骨化醇;化合物 T19559;(1R,3S,Z)-5-((E)-2-((1R,3AS,7AR)-1-((R,3E,5E)-7-乙基-7-羥基壬-3,5-迪恩-2-基)-7A-甲基六氫-1H-茚-4(2H)-亞乙基)-4-亞甲基環(huán)己烷-1,3-二醇;化合物 SEOCALCITOL;西奧骨化醇中間體;134404-52-7;EB1089;西奧骨化醇 /Seocalcitol |
| 英文名稱 | Seocalcitol |
| 英文同義詞 | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;Seocalcitol;(1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol;EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-;(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R,3E,5E)-7-Ethyl-7-hydroxynona-3,5-dien-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol;Theocalcitriol |
| CAS號 | 134404-52-7 |
| 分子式 | C30H46O3 |
| 分子量 | 454.68 |
| EINECS號 | |
| 相關(guān)類別 | 原料藥 |
| Mol文件 | 134404-52-7.mol |
| 結(jié)構(gòu)式 | ![]() |
西奧骨化醇 性質(zhì)
| 熔點 | 123-125° |
|---|---|
| 沸點 | 608.5±55.0 °C(Predicted) |
| 密度 | 1.06±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.29±0.29(Predicted) |
| 顏色 | 白色 |
| InChIKey | LVLLALCJVJNGQQ-QMWUBLQMSA-N |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@@H](/C=C/C=C/C(CC)(O)CC)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C |
Kd: 0.27 nM (vitamin D receptor)
Seocalcitol (EB 1089) is a stimulators of osteoclast recruitment in murine bone marrow cultures, with EC 50 at 0.1 nM. Seocalcitol stimulates bone resorption with an estimated EC 50 at 0.03 nM. Seocalcitol (EB 1089) elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC 50 =0.4±0.13). In the kidney, K d values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the K d for Seocalcitol is 1.43±0.19 nM). Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol (EB 1089) than for 1 nM VD 3 .
Seocalcitol (EB1089), a synthetic vitamin D analog, exhibits reduced hypercalcemic activity relative to 1,25(OH) 2 VD 3 . In another study, long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development. Seocalcitol (EB 1089) is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 危害水生環(huán)境-長期危害 類別4 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-32341 | 西奧骨化醇 Seocalcitol | 134404-52-7 | 1mg | 1200元 |
| 2026/06/05 | HY-32341 | 西奧骨化醇 Seocalcitol | 134404-52-7 | 5mg | 4440元 |
