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Shanghai Yifei Biotechnology Co. , Ltd.
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customer_service@efebio.com |
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Product Name:AS601245.2TFA (345987-15-7 free base)
CAS:345987-16-8
Purity:95.00% Package:1mg;2mg;5mg
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
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Product Name:AS601245.2TFA (345987-15-7 free base)
CAS:345987-16-8
Package:1mg/RMB 296;5mg/RMB 598;10mg/RMB 1110
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| Company Name: |
Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026 |
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Sales@sangon.com |
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Product Name:AS601245.2TFA (345987-15-7 free base)
CAS:345987-16-8
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| Company Name: |
Shanghai Amole Biotechnology Co., Ltd.
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18916360931 18916360931 |
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2596183085@qq.com |
| Products Intro: |
Product Name:AS601245.2TFA (345987-15-7 free base)
CAS:345987-16-8
Purity:5mg；50mg；25mg；200mg；1mg；10mg；100mg Package:-
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AS601245.2TFA (345987-15-7 free base) manufacturers
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| | AS601245.2TFA (345987-15-7 free base) Basic information |
| | AS601245.2TFA (345987-15-7 free base) Chemical Properties |
| | AS601245.2TFA (345987-15-7 free base) Usage And Synthesis |
| Uses | AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2]. | | in vivo | AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia[1].
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice[1]. | Animal Model: | C3H/HEN mice[1] | | Dosage: | 0.3, 1, 3, or 10 mg/kg | | Administration: | P.o. | | Result: | Decreased the TNF-α release in a dose-dependent manner.
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| | References | [1] Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310(1):25-32. DOI:10.1124/jpet.103.064246 |
| | AS601245.2TFA (345987-15-7 free base) Preparation Products And Raw materials |
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