BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
| 中文名稱 | BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
|---|---|
| 中文同義詞 | BIOTIN-SUBSTANCE P,BIOTIN-RPKPQQFFGLM-NH2;BIOTIN-神經(jīng)肽P物質(zhì);生物素標記P物質(zhì)肽BIOTIN-SUBSTANCE P;生物素化P物質(zhì) |
| 英文名稱 | BIOTINYL-SUBSTANCE P |
| 英文同義詞 | BIOTINYL-SUBSTANCE P;BIOTIN-SUBSTANCE P;BIOTIN-RPKPQQFFGLM-NH2;BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;substance P, alpha-biotinyl-Arg(1) -;Abasp;alpha-Biotinyl-1-Arg-substance p |
| CAS號 | 87468-58-4 |
| 分子式 | C73H112N20O15S2 |
| 分子量 | 1573.93 |
| EINECS號 | |
| 相關(guān)類別 | 多肽;標準品;peptide |
| Mol文件 | 87468-58-4.mol |
| 結(jié)構(gòu)式 |  |
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble in water at 2mg/ml; also soluble in acetonitrile |
Biotin-Substance P (Neurokinin P) 是一種神經(jīng)肽，在中樞神經(jīng)系統(tǒng)中作為神經(jīng)遞質(zhì)和神經(jīng)調(diào)節(jié)劑。Substance P 的內(nèi)源性受體是神經(jīng)激肽1受體 (neurokinin 1 receptor，NK1R)
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.