213546-53-3
| 中文名稱 | 213546-53-3 |
|---|---|
| 中文同義詞 | H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH;化合物 T12942;易位抑制劑多肽SN50;SN50多肽;SN50抑制劑;羅恩 SN50 R113056-1mg;SN50 ,S6671;羅恩 SN50 R113056-5mg |
| 英文名稱 | NFκB Inhibitor |
| 英文同義詞 | FGF-4 PRECURSOR (7-22) (HUMAN)-EBP-1 (359-368) (HUMAN);FIBROBLAST GROWTH FACTOR-4 PRECURSOR (7-22) (HUMAN)-NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT (359-368) (HUMAN);H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH;HST-1 PRECURSOR (7-22) (HUMAN)-DNA-BINDING FACTOR KBF1 (359-368) (HUMAN);AAVALLPAVLLALLAPVQRKRQKLMP;NF-KAPPA-B SN50;NF-KAPPA-B SN50, CELL-PERMEABLE INHIBITOR PEPTIDE;NF-KAPPAB SN50, CELL-PERMEABLE INHIBITORY PEPTIDE |
| CAS號 | 213546-53-3 |
| 分子式 | C129H230N36O29S |
| 分子量 | 2781.5 |
| EINECS號 | |
| 相關類別 | 標準品 |
| Mol文件 | 213546-53-3.mol |
| 結構式 | ![]() |
213546-53-3 性質
| 密度 | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | -20°C |
| 形態(tài) | 膜狀 |
| 顏色 | 無色 |
| 水溶解性 | Water : ≥ 50 mg/mL (17.98 mM) |
| 序列 | Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro |
| InChIKey | FAWLNURBQMTKEB-URDPEVQOSA-N |
| Target | Value |
|
NF-κB
() |
Pretreatment with SN50 results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups. Topical SN50 suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls. Treating the human gastric cancer cells SGC7901 with SN50 could significantly enhance the effects of LY294002 on inducing cell death after 24 h. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury.
Treatment with SN50 accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-P0151 | 213546-53-3 SN50 | 213546-53-3 | 1mg | 900元 |
| 2026/06/05 | HY-P0151 | 213546-53-3 SN50 | 213546-53-3 | 5mg | 3200元 |
