Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-
| 中文名稱(chēng) | Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- |
|---|---|
| 中文同義詞 | 化合物 T27434;化合物 GRN-529 |
| 英文名稱(chēng) | Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- |
| 英文同義詞 | Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-;GRN-529;(4-difluoromethoxy-3-pyridin-2-ylethynyl-phenyl)-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-methanone;GRN-529 >=97% (HPLC);2-{2-[2-(Difluoromethoxy)-5-{5H,6H,7H-pyrrolo[3,4-b]pyridine-6-carbonyl}phenyl]ethynyl}pyridine |
| CAS號(hào) | 1253291-12-1 |
| 分子式 | C22H15F2N3O2 |
| 分子量 | 391.37 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 1253291-12-1.mol |
| 結(jié)構(gòu)式 | ![Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- 結(jié)構(gòu)式](CAS/20150408/GIF/1253291-12-1.gif) |
Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- 性質(zhì)
Methanone, [4-(difluoroMethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- 用途與合成方法
GRN-529 是 mGluR5 的負(fù)向變構(gòu)調(diào)節(jié)劑 (NAM)。GRN-259 可以在大鼠體內(nèi)調(diào)節(jié)睡眠-清醒活動(dòng)，并表現(xiàn)出抗焦慮活性。