A-1210477
| 中文名稱 | A-1210477 |
|---|---|
| 中文同義詞 | 7-[5-[[4-[4-[(二甲基氨基)磺?；鵠-1-哌嗪基]苯氧基]甲基]-1,3-二甲基-1H-吡唑-4-基]-1-[2-(4-嗎啉基)乙基]-3-[3-(1-萘基氧基)丙基]-1H-吲哚-2-羧酸;MCL-1抑制劑(A-1210477);BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101;7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-嗎啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸;化合物A-1210477;A-1210477,MCL-1抑制劑;A-1210477 (A1210477);A-1210477 ,S7790 |
| 英文名稱 | A-1210477 |
| 英文同義詞 | A-1210477;Abbvie Mcl-1 Inhibitor;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;CS-2202;CS-2151;A-1210477;A 1210477;A1210477;1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]- |
| CAS號 | 1668553-26-1 |
| 分子式 | C46H55N7O7S |
| 分子量 | 850.04 |
| EINECS號 | |
| 相關類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;抑制劑;細胞生物學試劑;Inhibitors |
| Mol文件 | 1668553-26-1.mol |
| 結(jié)構(gòu)式 |  |
A-1210477 性質(zhì)
| 沸點 | 1027.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 儲存條件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 不溶于DMSO；不溶于水；不溶于乙醇 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 4.43±0.30(Predicted) |
| 顏色 | 白色至米白色 |
| InChIKey | MRLDHNSBXWSDDL-UHFFFAOYSA-N |
| SMILES | O=C(O)C(N1CCN2CCOCC2)=C(C3=C1C(C4=C(N(N=C4C)C)COC5=CC=C(C=C5)N6CCN(CC6)S(=O)(N(C)C)=O)=CC=C3)CCCOC7=C8C=CC=CC8=CC=C7.[H]Cl |
|
Mcl-1 0.45 nM (Ki) |
Bcl-2 132 nM (Ki) |
Bfl-1 660 nM (Ki) |
Bcl-W 2280 nM (Ki) |
Apoptosis
|
A-1210477 (10?μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC 50 of approximately 1?μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC 50 <10?μM, confirming that A-1210477 can kill MCL-1-dependent cell lines.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-12468 | A-1210477 | 1668553-26-1 | 1 mg | 266元 |
| 2026/06/05 | HY-12468 | 7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-嗎啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸 A-1210477 | 1668553-26-1 | 5mg | 700元 |