214558-72-2
| 中文名稱(chēng) | 214558-72-2 |
|---|---|
| 中文同義詞 | 化合物 T13372;化合物 YM-58790 HYDROCHLORIDE |
| 英文名稱(chēng) | YM-58790 |
| 英文同義詞 | YM-58790;YM58790,YM 58790;YM-58790 hydrochloride;[1-[[4-(Methylamino)phenyl]methyl]piperidin-4-yl] N-benzhydrylcarbamate hydrochloride |
| CAS號(hào) | 214558-72-2 |
| 分子式 | C27H32ClN3O2 |
| 分子量 | 466.02 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 214558-72-2.mol |
| 結(jié)構(gòu)式 |  |
214558-72-2 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
Ki: 15 nM (M3 muscarinic receptor)
YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro.
YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101679 | YM-58790 | 214558-72-2 | 1 mg | 1772元 |
| 2026/06/05 | HY-101679 | YM-58790 | 214558-72-2 | 5 mg | 3900元 |