3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
生物活性體外研究 用途與合成方法 MSDS 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) |
|---|---|
| 中文同義詞 | N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-六氫-3-羥基-10-甲氧基-9-甲基-1-氧代-9,13-環(huán)氧-1H,9H-二吲哚[1,2,3-GH:3′,2′,1′-LM]吡咯并[3,4-J][1,7]苯并二氮雜壬環(huán)-11-基]-N-甲基苯甲酰胺;化合物 (R)-3-Hydroxy Midostaurin |
| 英文名稱 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) |
| 英文同義詞 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2);(R)-3-Hydroxy Midostaurin;(R)-CGP52421;Midostaurin Impurity 2;Benzamide, N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-;Midostaurin Impurity 4;P39.8 (CGP52421 Epimer 2) |
| CAS號(hào) | 155848-20-7 |
| 分子式 | C35H30N4O5 |
| 分子量 | 586.65 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 155848-20-7.mol |
| 結(jié)構(gòu)式 |  |
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) 性質(zhì)
| 密度 | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系數(shù)(pKa) | 12.23±0.70(Predicted) |
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) 是有效的激酶抑制劑。(R)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通過(guò)肝 CYP3A4 酶代謝的主要代謝產(chǎn)物。(R)-3-Hydroxy Midostaurin 具有潛在的用于急性髓細(xì)胞性白血病 (AML) 的潛力。
(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC
50
values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme.
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI
50
=63 nM), KIT D816V (GI
50
=320 nM), and FLT3-ITD (GI
50
=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108263B | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) (R)-3-Hydroxy Midostaurin | 155848-20-7 | 1 mg | 3968元 |