2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-
生物活性靶點(diǎn)體內(nèi)研究 用途與合成方法 MSDS 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- |
|---|---|
| 中文同義詞 | 化合物 T10855;化合物CO23 |
| 英文名稱 | 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- |
| 英文同義詞 | 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-;CO23;CO23,CO-23;5-({4-[4-hydroxy-3-(propan-2-yl)phenoxy]-3,5-diiodophenyl}methyl)imidazolidine-2,4-dione |
| CAS號(hào) | 1370363-74-8 |
| 分子式 | C19H18I2N2O4 |
| 分子量 | 592.17 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1370363-74-8.mol |
| 結(jié)構(gòu)式 | ![2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- 結(jié)構(gòu)式](CAS/20200515/GIF/1370363-74-8.gif) |
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- 性質(zhì)
| 密度 | 1.878±0.06 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Store at -20°C |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 8.70±0.10(Predicted) |
| 顏色 | 米白色至淺黃色 |
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- 用途與合成方法
CO23 是一種選擇性的 TRα (甲狀腺激素受體)激動(dòng)劑，用于調(diào)節(jié)生長(zhǎng)發(fā)育。CO23 能夠通過(guò)血腦屏障轉(zhuǎn)運(yùn)。
TRα
CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.
| Animal Model: | Hypothyroid Wistar rats |
| Dosage: | 0.04, 0.8, 2.5, and 5.0 nmol/g |
| Administration: | Ip |
| Result: | Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-130012 | CO23 | 1370363-74-8 | 1 mg | 2900元 |
| 2026/06/05 | HY-130012 | 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- CO23 | 1370363-74-8 | 10 mM * 1 mLin DMSO | 9054元 |