2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
| 中文名稱 | 2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 |
|---|---|
| 中文同義詞 | 2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺;2-[(2-羥基萘-1-基亞甲基)氨基]-N-(1-苯乙基)苯甲酰胺;SIRTUIN抑制劑(SIRTINOL);西丁醇;化合物SIRTINOL;化合物SIRTINOL,10 MM DMSO 溶液;去乙?；?SIRTINOL, 去乙酰化酶 |
| 英文名稱 | SIRTINOL |
| 英文同義詞 | 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE;SIRTINOL;SIR TWO INHIBITOR NAPHTHOL;(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide;2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide;2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide;{2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol);Sirtinol - CAS 410536-97-9 - Calbiochem |
| CAS號 | 410536-97-9 |
| 分子式 | C26H22N2O2 |
| 分子量 | 394.47 |
| EINECS號 | |
| 相關類別 | 小分子抑制劑，天然產(chǎn)物;細胞生物學試劑;Inhibitors;Inhibitor;Other Enzyme Inhibitors.;Other enzyme inhibitors and activators |
| Mol文件 | 410536-97-9.mol |
| 結構式 | ![2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 結構式](CAS/GIF/410536-97-9.gif) |
2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 性質(zhì)
| 熔點 | 119-120℃ |
|---|---|
| 沸點 | 659.2±50.0 °C(Predicted) |
| 密度 | 1.16 |
| 儲存條件 | -20°C |
| 溶解度 | 溶于 DMSO（高達 30 mg/ml）。 |
| 形態(tài) | 黃色固體 |
| 酸度系數(shù)(pKa) | 7.85±0.50(Predicted) |
| 顏色 | 淡黃色低 |
| 水溶解性 | Soluble in water, DMSO and methanol |
| 穩(wěn)定性 | 可在-20°下的DMSO中的溶液儲存長達1個月。 |
| InChI | InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30) |
| InChIKey | UXJFDYIHRJGPFS-UHFFFAOYSA-N |
| SMILES | C(NC(C1=CC=CC=C1)C)(=O)C1=CC=CC=C1N=CC1=C2C(C=CC=C2)=CC=C1O |
|
ySir2 48 μM (IC 50 ) |
hSIRT2 57.7 μM (IC 50 ) |
hSIRT1 131 μM (IC 50 ) |
Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC 50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1.
Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury.
安全信息
| WGK Germany | 3 |
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| 存儲類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-13515 | 2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 Sirtinol | 410536-97-9 | 1 mg | 250元 |
| 2025/12/22 | HY-13515 | 2-[[(2-羥基-1-萘基)亞甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 Sirtinol | 410536-97-9 | 5mg | 550元 |