BCL2-associated X Protein (BAX) Mouse anti-Human Monoclonal AntibodyMouseMonoclonal

Human, Monkey, Mouse, Rat

UnconjugatedProduced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse BAX, and purified by antigen affinity chromatography.IHC - Paraffin (10 - 12 ug/ml), Western blot, Immunoprecipitation

LSBio:IHCPlus™ Monoclonal Mouse anti?Human BCL2 / Bcl?2 Antibody (clone 11C5, IHC, WB) LS?B7085

Bcl-2 antibody LS-B7085 is an unconjugated mouse monoclonal antibody to human Bcl-2 (BCL2). Validated for ELISA, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.

BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP).BAX(小鼠來源抗體)以人工合成的Bax氨基端(Amino-terminal)的一段多肽為抗原制備而成的抗Bax小鼠單克隆抗體?？寺√枮?A7(Clone6A7)，是應(yīng)用最廣的Bax抗體?？贵w類型為Mouse IgG1。