N-乙酰-L-胱氨酸
| 中文名稱 | N-乙酰-L-胱氨酸 |
|---|---|
| 中文同義詞 | N-乙酰-L-胱氨酸;N-乙?；?L-半胱氨酰胺;(2R)-2-乙酰氨-3-硫丙酰胺;乙?；?L-半胱氨酸;乙酰半胱氨酸雜質(zhì)14;(R) -2-乙酰氨基-3-巰基丙酰胺;N-乙酰半胱氨酸酰胺;N-乙酰-L-胱氨酸,10 MM DMSO 溶液 |
| 英文名稱 | N-Acetylcysteine amide |
| 英文同義詞 | PropanaMide,2-(acetylaMino)-3-Mercapto-, (2R)-;N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide;(R)- 2-(Acetylamino)-3-mercapto-Propanamide;acetylcysteinamide;AD4;(2R)-2-acetamido-3-sulfanylpropanamide;NACA;N-acetylcysteine amide |
| CAS號(hào) | 38520-57-9 |
| 分子式 | C5H10N2O2S |
| 分子量 | 162.21 |
| EINECS號(hào) | |
| 相關(guān)類別 | 雜質(zhì)對(duì)照品 |
| Mol文件 | 38520-57-9.mol |
| 結(jié)構(gòu)式 |  |
N-乙酰-L-胱氨酸 性質(zhì)
| 熔點(diǎn) | 147-149 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 沸點(diǎn) | 441.0±40.0 °C(Predicted) |
| 密度 | 1.226±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | H2O：≥20mg/mL |
| 酸度系數(shù)(pKa) | 9.21±0.10(Predicted) |
| 形態(tài) | 凍干粉 |
| 顏色 | 白色至類白色 |
| 水溶解性 | H2O: ≥20mg/mL DMSO: >40mg/mL |
| InChI | InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1 |
| InChIKey | ZLCOWUKVVFVVKA-GDVGLLTNSA-N |
| SMILES | C(N)(=O)[C@@H](NC(C)=O)CS |
| Target | Value |
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NF-κB
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HIF-1α
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ROS
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N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.
N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-110256 | N-乙酰-L-胱氨酸 N-Acetylcysteine amide | 38520-57-9 | 1mg | 363元 |
| 2026/06/05 | HY-110256 | N-乙酰-L-胱氨酸 N-Acetylcysteine amide | 38520-57-9 | 5mg | 800元 |