MIDAGLIZOLE HYDROCHLORIDE
| 中文名稱 | MIDAGLIZOLE HYDROCHLORIDE |
|---|---|
| 中文同義詞 | 咪格列唑鹽酸鹽;化合物 T11015;咪格列唑鹽酸鹽,10 MM DMSO 溶液 |
| 英文名稱 | 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride |
| 英文同義詞 | 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride;Midaglizole hydrochloride;Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2);Midaglizole hydrochloride, 10 mM in DMSO |
| CAS號 | 79689-25-1 |
| 分子式 | C16H19Cl2N3 |
| 分子量 | 0 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 79689-25-1.mol |
| 結(jié)構(gòu)式 |  |
MIDAGLIZOLE HYDROCHLORIDE 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Midaglizole hydrochloride (DG5128) 是有效的 α2-腎上腺素受體拮抗劑。Midaglizole hydrochloride (DG5128) 對 α2-腎上腺素能受體的親和力 (pKi= 6.28) 比 α1-腎上腺素能受體高 7.4 倍。
pKi :6.28 (α2-adrenoceptor)
Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [ 3 H]clonidine binding more effectively than it doed [ 3 H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action. The EC 50 values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC 50 values for K ATP current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively.
Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-U00165 | Midaglizole hydrochloride | 79689-25-1 | 1 mg | 1035元 |
| 2026/06/05 | HY-U00165 | MIDAGLIZOLE HYDROCHLORIDE Midaglizole hydrochloride | 79689-25-1 | 5 mg | 2663元 |