NEVANIMIBE HYDROCHLORIDE
| 中文名稱 | NEVANIMIBE HYDROCHLORIDE |
|---|---|
| 中文同義詞 | 化合物NEVANIMIBE HYDROCHLORIDE;ATR-101鹽酸鹽;化合物NEVANIMIBE HYDROCHLORIDE,10 MM DMSO 溶液 |
| 英文名稱 | PD 132301-2 |
| 英文同義詞 | PD 132301-2;ATR-101 HCl;Nevanimibe hydrochloride;ATR-101 (PD-132301;Nevanimibe);ATR101 hydrochloride;PD-132301 hydrochloride;cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor |
| CAS號(hào) | 133825-81-7 |
| 分子式 | C27H40ClN3O |
| 分子量 | 458.09 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 133825-81-7.mol |
| 結(jié)構(gòu)式 |  |
NEVANIMIBE HYDROCHLORIDE 性質(zhì)
| 儲(chǔ)存條件 | 4°C, away from moisture |
|---|---|
| 溶解度 | DMSO：41.67 mg/mL（90.97 mM；需要超聲波）| （不溶） |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
| InChI | 1S/C27H39N3O.ClH/c1-19(2)23-10-9-11-24(20(3)4)25(23)29-26(31)28-18-27(16-7-8-17-27)21-12-14-22(15-13-21)30(5)6;/h9-15,19-20H,7-8,16-18H2,1-6H3,(H2,28,29,31);1H |
| InChIKey | SDOOGTHIDFZUNM-UHFFFAOYSA-N |
| SMILES | [Cl-].N(C)(C)c1ccc(cc1)C3(CCCC3)CNC(=O)Nc2c(cccc2C(C)C)C(C)C.[H+] |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一種口服有效的，選擇性?；o酶 A：膽固醇 O-?；D(zhuǎn)移酶 1 (ACAT1) 抑制劑，EC50 為 9 nM。Nevanimibe hydrochloride 抑制 ACAT2，EC50 為 368 nM。Nevanimibe hydrochloride 誘導(dǎo)細(xì)胞凋亡 (apoptosis)，并具有抗腎上腺皮質(zhì)癌的潛力。
|
ACAT1 9 nM (EC 50 ) |
ACAT2 368 nM (EC 50 ) |
Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
Cell Cytotoxicity Assay
| Cell Line: | The H295R and HAC clone 15 (HAC15) human ACC cell lines |
| Concentration: | 3 nM-30 μM |
| Incubation Time: | 24 hours |
| Result: | 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100399AR | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride (Standard) | 133825-81-7 | 1 mg | 1000元 |
| 2026/06/05 | HY-100399AR | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride (Standard) | 133825-81-7 | 5 mg | 2500元 |