KB 5492
| 中文名稱 | KB 5492 |
|---|---|
| 中文同義詞 | 化合物 T24254;化合物 KB-5492 ANHYDROUS;4-甲氧基苯基 2-(4-(3,4,5-三甲氧基芐基)哌嗪-1-基)乙酸酯 富馬酸鹽 |
| 英文名稱 | KB 5492 |
| 英文同義詞 | KB 5492;KB-5492 anhydrous;KB 5492 anhydrous,KB5492 anhydrous;1-(3,4,5-Trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine |
| CAS號(hào) | 129200-10-8 |
| 分子式 | C27H34N2O10 |
| 分子量 | 546.57 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 129200-10-8.mol |
| 結(jié)構(gòu)式 |  |
KB 5492 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亞砜：250 mg/mL（457.40 mM） |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
KB-5492 anhydrous 是一種有效的和選擇性的 sigma 受體抑制劑，抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 與 sigma 受體結(jié)合，IC50 值為 3.15 μM。KB-5492 anhydrous 是一種抗?jié)兯帯?div id="rctofyo7" class="gsbt">靶點(diǎn)
IC50: 3.15 μM (sigma receptor)
KB-5492 (0.001-100 μM) inhibits specific [
3
H]DTG binding in a concentration-dependent manner.
KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in
51
Cr release from gastric epithelial cells.
KB-5492 (200?mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa.
| Animal Model: | Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage |
| Dosage: | 200?mg/kg |
| Administration: | Oral gavage |
| Result: |
Reduced the lesion length as compared with the control.
Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-19120 | KB-5492 anhydrous | 129200-10-8 | 1 mg | 1800元 |
| 2026/06/05 | HY-19120 | KB 5492 KB-5492 anhydrous | 129200-10-8 | 5mg | 4300元 |