GAP26
| 中文名稱 | GAP26 |
|---|---|
| 中文同義詞 | VR-13;化合物GAP 26;GAP 26游離態(tài);H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH;穿膜肽GAP 26;間隙連接的阻斷肽:GAP26;GAP26 TRIFLUOROACETATE;GAP 26,GAP JUNCTION BLOCKING多肽 |
| 英文名稱 | GAP 26 |
| 英文同義詞 | GAP 26;M.W. 1550.78 C70H107N19O19S;Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg;43Gap 26, Connexin Mimetic;GAP-26; GAP26;L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-;GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75);Gap26 trifluoroacetate |
| CAS號(hào) | 197250-15-0 |
| 分子式 | C70H107N19O19S |
| 分子量 | 1550.78 |
| EINECS號(hào) | |
| 相關(guān)類別 | 目錄肽;目錄多肽;CancerBiology;Various Peptides |
| Mol文件 | 197250-15-0.mol |
| 結(jié)構(gòu)式 |  |
GAP26 性質(zhì)
| 密度 | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 不溶于乙醇；超聲檢測(cè)水中≥155.1 mg/mL； DMSO 中≥77.55 mg/mL，溫和加熱和超聲波 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 3.31±0.10(Predicted) |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble to 2 mg/ml in water |
| 序列 | H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH |
| InChIKey | FDPIMWZHGJNESB-VCSXYVMHSA-N |
Gap 26 是一種連接蛋白模擬肽，由連接蛋白connexin 43 (Cx43)的細(xì)胞外環(huán)1的殘基 no. 63-75組成，是 gap junction 的抑制劑。Gap 26 可阻止光解inositol-1,4,5-trisphosphate觸發(fā)的ATP釋放。
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
| Target | Value |
|
gap junction
() |
Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC
50
of 28.4 ± 3.4 μM.
參考質(zhì)量標(biāo)準(zhǔn)
外觀:白色粉末純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海關(guān)編碼 | 2922498590 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0339 | GAP26 Gap 26 | 197250-15-0 | 5mg | 3251.43元 |
| 2026/07/06 | S0339 | GAP26 Gap 26 | 197250-15-0 | 25mg | 9819.81元 |