靈芝酸D
| 中文名稱(chēng) | 靈芝酸D |
|---|---|
| 中文同義詞 | 靈芝酸D;靈芝酸D對(duì)照品,;靈芝酸D標(biāo)準(zhǔn)品;靈芝酸 D,10 MM DMSO 溶液;靈芝酸DGanoderic acid D;Ganoderic acid D靈芝酸 D;靈芝酸DGanoderic acid D;Ganoderic acid D靈芝酸 D |
| 英文名稱(chēng) | Ganoderic acid D |
| 英文同義詞 | (7beta)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid;Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)-;cyclophilin,colon,CypD,Ganoderic acid D,human,Apoptosis,inhibit,oxygenated,Sirtuin,tetracyclic,cancer,carcinoma,HeLa,triterpenoid,Inhibitor,deacetylated,cervical;Ganoderic acid D-RM;Ganoderic acid D, 10 mM in DMSO;Ganoderic acid D (Standard) |
| CAS號(hào) | 108340-60-9 |
| 分子式 | C30H42O7 |
| 分子量 | 514.65 |
| EINECS號(hào) | |
| 植物來(lái)源 | 靈芝 |
| 相關(guān)類(lèi)別 | 三萜;植物提取物;對(duì)照品，標(biāo)準(zhǔn)品;中藥對(duì)照品;標(biāo)準(zhǔn)品;對(duì)照品;對(duì)照品-中藥對(duì)照品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-對(duì)照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;標(biāo)準(zhǔn)品，對(duì)照品 |
| Mol文件 | 108340-60-9.mol |
| 結(jié)構(gòu)式 |  |
靈芝酸D 性質(zhì)
| 沸點(diǎn) | 688.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C, protect from light |
| 溶解度 | 溶于甲醇； |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 4.77±0.23(Predicted) |
| 顏色 | 白色 |
| 水溶解性 | insoluble in water |
| InChIKey | YTVGSCZIHGRVAV-IYAQLQCNSA-N |
| SMILES | O[C@H]1C[C@@H]2[C@](CCC(=O)C2(C)C)(C3=C1[C@]4([C@@]([C@H](CC4=O)[C@@H](CC(=O)CC(C)C(=O)O)C)(CC3=O)C)C)C |
Ganoderic acid D 是一種高度氧化的四環(huán)三萜類(lèi)化合物 (tetracyclic triterpenoid)，是靈芝 (Ganoderma lucidum) 的主要活性成分。Ganoderic acid D 上調(diào) SIRT3 的蛋白質(zhì)表達(dá)并通過(guò) SIRT3 誘導(dǎo)脫乙酰化的親環(huán)蛋白 D (CypD)。Ganoderic acid D 抑制結(jié)腸癌細(xì)胞的能量重編程，包括結(jié)腸癌細(xì)胞中的葡萄糖攝取，乳酸產(chǎn)生，丙酮酸和乙酰輔酶的產(chǎn)生。Ganoderic acid D 誘導(dǎo) HeLa 人宮頸癌細(xì)胞凋亡 (apoptosis)。
藥理藥效:抗腫瘤，保肝，心血管方面作用
|
SIRT3
|
Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC
50
of 17.3 mM.
Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner.
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest.
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells.
Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3.
Cell Viability Assay
| Cell Line: | HeLa human cervical carcinoma cell line (CCL-2) |
| Concentration: | 1, 5, 10, 20, 50 μM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Reduced the cell survival rate in a dose- and time-dependent manner and had an IC 50 value of 17.3 μM for 48 hours treatment. |
Cell Cycle Analysis
| Cell Line: | HeLa human cervical carcinoma cell line (CCL-2) |
| Concentration: | 10, 50 μM |
| Incubation Time: | 24, 48 hours |
| Result: |
Induced G2/M phase arrest.
Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM. |
Apoptosis Analysis
| Cell Line: | HeLa human cervical carcinoma cell line (CCL-2) |
| Concentration: | 10, 50 μM |
| Incubation Time: | 48 hours |
| Result: | Induced a morphological change typical of apoptosis in HeLa cells. |
Western Blot Analysis
| Cell Line: | HeLa human cervical carcinoma cell line (CCL-2) |
| Concentration: | 10 μM |
| Incubation Time: | 48 hours |
| Result: | Up-regulated 14-3-3E and PRDX3. |
化學(xué)性質(zhì)
白色粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于多孔菌科靈芝Ganodermalucidum（Leyss.exFr.）Karst．的干燥子實(shí)體。用途
靈芝酸D具有降血脂、降血壓的作用。用途
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等藥理藥效:抗腫瘤，保肝，心血管方面作用
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N1511 | 靈芝酸D Ganoderic acid D | 108340-60-9 | 1 mg | 811元 |
| 2026/06/05 | HY-N1511 | 靈芝酸D Ganoderic acid D | 108340-60-9 | 5 mg | 1988元 |