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Postion:Product Catalog >LCB-2853
LCB-2853
  • LCB-2853

LCB-2853 NEW

Price $700 $1800
Package 1mg 5mg
Supply Ability: 10g
Update Time: 2025-08-22

Product Details

Product Name: LCB-2853 CAS No.: 141335-10-6
Purity: 97.15% Supply Ability: 10g
Release date: 2025/08/22

Product Introduction

Bioactivity

NameLCB-2853
DescriptionLCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
In vivoIn dog coronary stenosis, LCB 2853 demonstrates high efficacy with an ED50 of 7.2 μg/kg. In rat venous thrombosis induced by venous injury and blood stasis, perfused LCB 2853 reduces thrombus weight in a dose-dependent manner with an ED50 of 220 μg/kg/min[1]. In vivo, LCB 2853 shows an ED50 below 1 mg/kg i.v. against platelet aggregation and vasoconstriction, observed in rat arachidonic acid (AA)-induced thrombocytopenia or U 46619-induced hypertension (ED50 = 0.25 and 0.16 mg/kg) and in AA-induced sudden death in mice (ED50 = 0.44 mg/kg). Additionally, LCB 2853 effectively blocks U 46619-induced bronchoconstriction after i.v. administration (ED50 = 18.4 μg/kg)[2].
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
KeywordsTXA2R | TXA2 Receptor | LCB-2853 | LCB2853 | LCB 2853
Inhibitors RelatedPHYTOL | (S)-(+)-Ibuprofen | BADGE | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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