Zamicastat NEW
| Price | $88 | $215 | $325 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Zamicastat | CAS No.: 1080028-80-3 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Zamicastat |
| Description | Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) and a concentration-dependent dual inhibitor of P-gp and BCRP, with IC50 values of 73.8 μM and 17.0 μM, respectively. |
| In vivo | In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (373.63 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.96 mM), Sonication is recommended. |
| Keywords | Zamicastat | P-gp?(P-glycoprotein) | P-gp | Pgp | P-glycoprotein | Multidrug resistance protein 1 | MDR1 | Inhibitor | inhibit | Dopamine β-monooxygenase | Dopamine β-hydroxylase | Dopamine beta-monooxygenase | Dopamine beta-hydroxylase | Cluster of differentiation 243 | CD243 | Breast cancer resistance protein | BCRP | ABCG2 | ABCB1 |
| Inhibitors Related | Trifluoperazine dihydrochloride | Verapamil hydrochloride | Glibenclamide | Casein | pCPA methyl ester hydrochloride | Ketoconazole | 4-Chloro-L-phenylalanine | Polyoxyethylene stearate | Fenclonine | Tariquidar | Acridone | Cinchonine |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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