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[CAS NO. 55449-49-5]??Anisodamine hydrobromide

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PRODUCTS SPECIFICATIONS [55449-49-5]

Catalog
HY-N0584A
Brand
MCE
CAS
55449-49-5

DESCRIPTION [55449-49-5]

Overview

MDL-
Molecular Weight386.28
Molecular FormulaC17H24BrNO4
SMILESCN1[C@H]2[C@@H](O)C[C@@H]1C[C@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C2.Br

For research use only. We do not sell to patients.

Summary

Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties [1] [2] .


IC50 & Target

Nicotinic cholinoceptor [1]


In Vitro

Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone [2] .
Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20% [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-Induced Shock Mice [2]
Dosage: 50 mg/kg
Administration: I.p.
Result: Markedly decreased the mortality to 20%.

Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT01929044 Boehringer Ingelheim
Intestinal Diseases
August 2013 Phase 3
NCT02442440 Jinhua Central Hospital
Septic Shock
April 2015 Phase 1|Phase 2

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 258.88 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5888 mL 12.9440 mL 25.8880 mL
5 mM 0.5178 mL 2.5888 mL 5.1776 mL
10 mM 0.2589 mL 1.2944 mL 2.5888 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

* All of the co-solvents are available by MCE.


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