4 | 1126721-79-6 | | 舒尼替尼 d4 | Isotope-Labeled Compounds | VEGFR | PDGFR | IRE1 | Mitophagy | Autophagy | Apoptosis | Vascular endothelial growth factor receptor | Platelet-derived growth factor receptor | Inositol requiring enzyme 1 | Mitochondrial Autophagy | Inhibitor | inhibitor | inhibit"/>

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  1. Others Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Autophagy Apoptosis
  2. Isotope-Labeled Compounds VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis
  3. Sunitinib-d4

Sunitinib-d4 是 Sunitinib 的氘代物。Sunitinib (SU 11248) 是一種多靶點(diǎn)受體酪氨酸激酶抑制劑,抑制 VEGFR2PDGFRβIC50 分別為 80 nM 和 2 nM。Sunitinib 是ATP 競爭性抑制劑,可通過抑制自身磷酸化和隨后的 RNase 激活來有效抑制 Ire1α 的磷酸化。

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Sunitinib-d<sub>4</sub>

Sunitinib-d4 Chemical Structure

CAS No. : 1126721-79-6

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規(guī)格 價(jià)格 是否有貨
1 mg ¥5950
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Other Forms of Sunitinib-d4:

查看 VEGFR 亞型特異性產(chǎn)品:

查看 PDGFR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Sunitinib-d4 is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

產(chǎn)品應(yīng)用

1. 該化合物可作為示蹤劑。
2. 該化合物可作為 NMR、GC-MS 或 LC-MS 分析中的內(nèi)標(biāo)品,用于定量分析。

體外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

402.50

Formula

C22H23D4FN4O2

CAS 號(hào)
非標(biāo)記 CAS
中文名稱

舒尼替尼 d4

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

純度 & 產(chǎn)品資料
參考文獻(xiàn)
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產(chǎn)品名稱:
Sunitinib-d4
目錄號(hào):
HY-10255AS1
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