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  2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Adrenergic Receptor NADPH Oxidase
  4. (Rac)-Nebivolol

(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋異構體。Nebivolol 是一種具有選擇性的β1 腎上腺素能受體拮抗劑，IC50 為 0.8 nM。在乙醇引起心臟毒性的早期階段，Nebivolol 能預防 Nox2/NADPH 氧化酶上調(diào)和脂質(zhì)過氧化。具有血管舒張活性。

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(Rac)-Nebivolol

(Rac)-Nebivolol Chemical Structure

CAS No. : 99200-09-6

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規(guī)格 價格 是否有貨
1 mg ￥1600
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5 mg ￥3500
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10 mg ￥5600
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Customer Review

Other Forms of (Rac)-Nebivolol:

查看 Adrenergic Receptor 亞型特異性產(chǎn)品:

查看 NADPH Oxidase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2].

IC50 & Target

NOX2

 

體內(nèi)研究
(In Vivo)

Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

405.44

Formula

C22H25F2NO4
CAS 號
中文名稱

(Rac)-奈必洛爾
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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  • 稀釋計算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(Rac)-Nebivolol
目錄號：
HY-B0203B
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