Oxotremorine sesquifumarate

SKU: orb1940371

Description

Oxotremorine sesquifumarate is a muscarinic receptor agonist.(In Vitro):Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.(In Vivo):Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores.

Images & Validation

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Key Properties

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CAS Number	17360-35-9
MW	760.794
Purity	>98% (HPLC)
Formula	C₃₆H₄₈N₄O₁₄
SMILES	OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1
Target	AChR
Solubility	In Vitro: DMSO : 125 mg/mL (328.60 mM)

Bioactivity

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In Vivo	In rats with sciatic nerve injuries, Oxotremorine (10, 5, 21 μg; 10 μL) i. t. dose-dependently suppresses the tactile hypersensitivity.
In Vitro	Oxotremorine (10.5 μM) produces a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

AChR

Protocol Information

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