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Beclomethasone 17-propionate

SKU: orb1992940

Description

Beclomethasone 17-propionate (17-BMP) is the active glucocorticoid metabolite of beclomethasone dipropionate. With 13-fold greater GR affinity than BDP, it potently suppresses pro-inflammatory cytokines like CXCL8, TNF-α, and IL-6. This mechanism underpins its research applications in studying asthma and allergic rhinitis pathophysiology in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number5534-18-9
MW464.98
Purity98.06% (May vary between batches)
FormulaC25H33ClO6
SMILESO(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
TargetGlucocorticoid Receptor,Drug Metabolite
Solubility10% DMSO+90% Corn Oil:3.3 mg/mL (7.1 mM);DMSO:100 mg/mL (215.06 mM)

Bioactivity

In Vitro
Beclomethasone 17-propionate has EC50 values ​​of 0.05 nM, 0.01 nM, and 0.1 nM for IL-6, TNFα, and CXCL8, respectively.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

17-BMP, Beclomethasone, Beclomethasone 17 propionate, Beclomethasone 17propionate, Beclomethasone 17-propionate, Beclomethasone-17-monopropionate
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 340.00
100 mg
$ 490.00
200 mg
$ 690.00
DispatchUsually dispatched within 5-10 working days
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