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  2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (2R,4R)-APDC

(2R,4R)-APDC 是一種群 II 型代謝型谷氨酸受體 (mGluR) 激動劑。(2R,4R)-APDC 通過抑制谷氨酸釋放、增強(qiáng) D1 受體激活產(chǎn)生的運(yùn)動反應(yīng)或降低腦源性神經(jīng)營養(yǎng)因子 (BDNF) 的水平來影響細(xì)胞增殖。(2R,4R)-APDC 可用于癲癇和其他神經(jīng)系統(tǒng)疾病的研究。

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(2R,4R)-APDC

(2R,4R)-APDC Chemical Structure

CAS No. : 169209-63-6

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥4294
3 - 4 周
10 mg 詢價 3 - 4 周
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of (2R,4R)-APDC:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases[1][2].

IC50 & Target[1]

group II mGlu receptors

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
> 100 μM
Compound: 18
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
體內(nèi)研究
(In Vivo)

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
Dosage: 1 nmol/10 μl; 10 nmol/10μl
Administration: ICV; daily for 14 days
Result: Resulted in decreased BrdU-immunoreactive cells in the DG.
分子量

174.15

Formula

C6H10N2O4
CAS 號
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • 稀釋計(jì)算器

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質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(2R,4R)-APDC
目錄號：
HY-102091
需求量：
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