一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Life sciences >>article
Life sciences

Life sciences

IF: 5.2
Download PDF

AMPK activation reduces cancer cell aggressiveness via inhibition of monoamine oxidase A (MAO-A) expression/activity

Published:22 June 2024 DOI: 10.1016/j.lfs.2024.122857 PMID: 38914305
Chandreyee Datta, Payel Das, Subhajit Dutta, Tuhina Prasad, Abhineet Banerjee, Sameep Gehlot, Arpa Ghosal, Sukhamoy Dhabal, Pritam Biswas, Debojyoti De, Surabhi Chaudhuri, Ashish Bhattacharjee

Abstract

Aim

AMPK can be considered as an important target molecule for cancer for its unique ability to directly recognize cellular energy status. The main aim of this study is to explore the role of different AMPK activators in managing cancer cell aggressiveness and to understand the mechanistic details behind the process.

Main methods

First, we explored the AMPK expression pattern and its significance in different subtypes of lung cancer by accessing the TCGA data sets for LUNG, LUAD and LUSC patients and then established the correlation between AMPK expression pattern and overall survival of lung cancer patients using Kaplan-Meire plot. We further carried out several cell-based assays by employing different wet lab techniques including RT-PCR, Western Blot, proliferation, migration and invasion assays to fulfil the aim of the study.

Key findings

  • ?

    Expression of AMPK is correlated with survival and prognosis of lung cancer patients.

  • ?

    AMPK activators like Metformin and Phenformin downregulate A549 and HCT-116 cell proliferation and migration via repression of p38MAPK activity, subsequent augmentation of R1 repressor and corresponding downregulation of MAO-A expression/activity resulting reduction in the intracellular ROS.

  • ?

    SRT-1720 directly activates AMPK in LKB1 mutant A549 cells either alone or in combination with Metformin resulting regulation of cancer cell aggressiveness.

Significance

This study identifies the importance of AMPK activators as a repurposing agent for combating lung and colon cancer cell aggressiveness. It also suggests SRT-1720 as a potent repurposing agent for cancer treatment especially in NSCLC patients where a point mutation is present in LKB1.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 925434-55-5 C25H23N7OS 77 suppliers $39.00-$2730.00
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 925434-55-5 C25H23N7OS 77 suppliers $39.00-$2730.00
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 925434-55-5 C25H23N7OS 77 suppliers $39.00-$2730.00
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 925434-55-5 C25H23N7OS 77 suppliers $39.00-$2730.00

Similar articles

IF:4.3

Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors.

ACS Applied Electronic Materials Tünde Kovács, Edit Mikó,etc Published: 4 February 2019
IF:12.7

Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.

ACS Central Science Sabrina Baltschukat, Barbara Schacher Engstler,etc Published: 15 May 2019
IF:4.8

9‐Methylfascaplysin Prevents Neuroinflammation and Synaptic Damage via Cell‐Specific Inhibition of Kinases in?APP/PS1 Transgenic Mice

CNS Neuroscience & Therapeutics Jingyang Le, Chenglong Xia,etc Published: 19 November 2024
全南县| 石台县| 高淳县| 黑河市| 东辽县| 洛扎县| 广饶县| 宁陕县| 临江市| 太康县| 石景山区| 贡山| 金塔县| 浮山县| 颍上县| 象州县| 德令哈市| 禹城市| 城口县| 昭通市| 乌兰县| 沙湾县| 碌曲县| 太原市| 丰县| 余姚市| 丹棱县| 镇康县| 永顺县| 济源市| 肥东县| 本溪市| 沧源| 岑巩县| 新和县| 西吉县| 三门峡市| 和林格尔县| 佛学| 宜川县| 凤冈县|