| Identification | Back Directory | [Name]
2-[[2-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]acetyl]amino]acetic acid | [CAS]
1010913-79-7 | [Synonyms]
Glycine, N-[2-[2-(2-fluorophenyl)-4-thiazolyl]acetyl]-
2-[[2-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]acetyl]amino]acetic acid | [Molecular Formula]
C13H11FN2O3S | [MOL File]
1010913-79-7.mol | [Molecular Weight]
294.3 |
| Hazard Information | Back Directory | [Uses]
SJ6145 is a potent ligand for KLHDC2SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2SBD binding to a di-Gly degron peptide test[1]. | [IC 50]
KLHDC2 | [References]
[1] Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. DOI:10.1038/s41467-024-52966-3 |
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