| Identification | Back Directory | [Name]
1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αR)- | [CAS]
1021736-25-3 | [Synonyms]
(R)-MK-5046
1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αR)- | [Molecular Formula]
C20H18F6N4O | [MOL File]
1021736-25-3.mol | [Molecular Weight]
444.37 |
| Chemical Properties | Back Directory | [Boiling point ]
571.6±50.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.22±0.15(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity[1][2][3]. | [References]
[1] Guan XM, et al. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364. DOI:10.1124/jpet.110.174763
[2] Sebhat IK, et al. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2010 Oct 18;2(1):43-47. DOI:10.1021/ml100196d
[3] Ramos-Alvarez I, et al. The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. J Pharmacol Exp Ther. 2022 Aug;382(2):66-78. DOI:10.1124/jpet.121.001033 |
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