| Identification | Back Directory | [Name]
Esculentic acid | [CAS]
103974-74-9 | [Synonyms]
Esculentic acid
2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid
Urs-12-en-28-oic acid,2,3,23-trihydroxy-, (2a,3a,4a)- | [Molecular Formula]
C30H48O5 | [MOL File]
103974-74-9.mol | [Molecular Weight]
488.71 |
| Chemical Properties | Back Directory | [Melting point ]
270-272 °C | [Boiling point ]
609.4±55.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.66±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Esculentic acid has anti-inflammatory effect.
Esculentic acid has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice. | [Uses]
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta[1][2]. | [Definition]
ChEBI: 2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid is a pentacyclic triterpenoid that is urs-12-ene substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3alpha stereoisomer). It has been isolated from Juglans sinensis. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of an ursane. | [target]
COX | TNF-α | IL Receptor | [References]
[1] Niu X, et al. Esculentic acid, a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro. Eur J Pharmacol. 2014 Oct 5;740:532-8. DOI:10.1016/j.ejphar.2014.06.034
[2] Niu X, et al. Protective effects of esculentic acid against endotoxic shock in Kunming mice. Int Immunopharmacol. 2014 Nov;23(1):229-35. DOI:10.1016/j.intimp.2014.08.022 |
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