| Identification | Back Directory | [Name]
5-Oxazolecarboxylic acid, 2-bromo-, ethyl ester | [CAS]
1060816-22-9 | [Synonyms]
2-bromooxazoL
Ethyl 2-broMo-oxazol-5-carboxylate
Ethyl 2-broMooxazole-5-carboxylate
ethyl 2-broMo-1,3-oxazole-5-carboxylate
2-Bromo-5-oxazolecarboxylic acid ethyl ester
2-BroMo-oxazole-5-carboxylic acid ethyl ester
5-Oxazolecarboxylic acid, 2-bromo-, ethyl ester | [Molecular Formula]
C6H6BrNO3 | [MDL Number]
MFCD09743496 | [MOL File]
1060816-22-9.mol | [Molecular Weight]
220.02 |
| Chemical Properties | Back Directory | [Boiling point ]
272.2±32.0 °C(Predicted) | [density ]
1.617±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
-2?+-.0.10(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C6H6BrNO3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3 | [InChIKey]
VZYKDUOPMKESLS-UHFFFAOYSA-N | [SMILES]
O1C(C(OCC)=O)=CN=C1Br |
| Hazard Information | Back Directory | [Uses]
Ethyl 2-bromooxazole-5-carboxylate is an organic synthesis intermediate. In the synthesis of novel topoisomerase II inhibitors (such as IID432), this compound serves as a coupling substrate for the construction of the oxazole ring core structure [1]. | [References]
[1] Olivier René, Manuel Saldivia, Maxime Dauphinais, et al. (2026). Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model. Journal of medicinal chemistry, 69(2), 1135–1153. https://doi.org/10.1021/acs.jmedchem.5c02459 |
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