ChemicalBook--->CAS DataBase List--->106392-48-7

106392-48-7

    1. 106392-48-7 Structure

      106392-48-7 Structure
      IdentificationBack Directory
      [Name]

      2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
      [CAS]

      106392-48-7
      [Synonyms]

      ST 271
      ST271, >98%
      ST271;ST 271;ST-271
      2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
      [Molecular Formula]

      C16H20N2O2
      [MDL Number]

      MFCD31544351
      [MOL File]

      106392-48-7.mol
      [Molecular Weight]

      272.34
      Chemical PropertiesBack Directory
      [Boiling point ]

      468.4±45.0 °C(Predicted)
      [density ]

      1.137±0.06 g/cm3(Predicted)
      [storage temp. ]

      Sealed in dry,2-8°C
      [solubility ]

      DMSO : ≥ 110 mg/mL (403.91 mM)
      [form ]

      Solid
      [pka]

      10.05±0.40(Predicted)
      [color ]

      Light yellow to yellow
      Safety DataBack Directory
      [Symbol(GHS) ]

      Exclamation Mark (GHS07)
      GHS07
      [Signal word ]

      Warning
      [Hazard statements ]

      H302-H315-H319-H335
      [Precautionary statements ]

      P261-P305+P351+P338
      Hazard InformationBack Directory
      [Uses]

      ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
      [Biological Activity]

      ST271 is a tyrosine phosphorylation inhibitor that inhibits phospholipase D activity.
      [in vitro]

      ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30% ) but significant inhibition of the response to thrombin and U46619.

      [target]

      TargetValue
      PLD
      ()
      [References]

      [1] Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID:7526916
      [2] Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor. DOI:10.1016/0014-5793(94)80575-x
      [3] Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt 3):597-600. DOI:10.1042/bj2810597
      Spectrum DetailBack Directory
      [Spectrum Detail]

      2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-(106392-48-7)1HNMR
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