| Identification | Back Directory | [Name]
2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)- | [CAS]
106392-48-7 | [Synonyms]
ST 271 ST271, >98% ST271;ST 271;ST-271 2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)- | [Molecular Formula]
C16H20N2O2 | [MDL Number]
MFCD31544351 | [MOL File]
106392-48-7.mol | [Molecular Weight]
272.34 |
| Chemical Properties | Back Directory | [Boiling point ]
468.4±45.0 °C(Predicted) | [density ]
1.137±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : ≥ 110 mg/mL (403.91 mM) | [form ]
Solid | [pka]
10.05±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively. | [Biological Activity]
ST271 is a tyrosine phosphorylation inhibitor that inhibits phospholipase D activity. | [in vitro]
ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30% ) but significant inhibition of the response to thrombin and U46619. | [target]
| Target | Value | PLD () | table>[References]
[1] Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID:7526916 [2] Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor. DOI:10.1016/0014-5793(94)80575-x [3] Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt 3):597-600. DOI:10.1042/bj2810597 |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|
|
Tags:106392-48-7
Related Product Information
|
|
|
永寿县|
武陟县|
夏邑县|
根河市|
翼城县|
普陀区|
叶城县|
苏尼特右旗|
寿阳县|
铜山县|
关岭|
平山县|
东乡族自治县|
鄂托克前旗|
樟树市|
杨浦区|
息烽县|
新竹市|
泌阳县|
江孜县|
阿合奇县|
北安市|
苍南县|
陆丰市|
佛坪县|
茶陵县|
开封市|
抚宁县|
湾仔区|
左贡县|
敦煌市|
启东市|
灵寿县|
内黄县|
鄂伦春自治旗|
青岛市|
许昌县|
舞钢市|
鞍山市|
东莞市|
简阳市|
|